Pathology of polyarteritis nodosa

Topic: Pathology

Created on Friday, December 7 2007 by jdmiles

Last modified on Friday, December 7 2007.

 
        A) Neutrophilic inflammation of the arteries
 
        B) Thickened arteries with granular, periodic acid-Schiff-positive material in the media
 
        C) Inflammation of the arteries, with multinucleated giant cells proliferating in the intimal layer
 
        D) Granular osmiophilic material seen on electron microscopy
 
        E) Amyloid deposition in the media of the artery
 

 

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This question was created on December 07, 2007 by jdmiles.
This question was last modified on December 07, 2007.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS

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A) Neutrophilic inflammation of the arteries

This answer is correct.

Neutrophilic inflammation of the arteries is the characteristic pathologic finding in polyarteritis nodosa.  (See References)

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B) Thickened arteries with granular, periodic acid-Schiff-positive material in the media

This answer is incorrect.

Thickened arteries with granular, periodic acid-Schiff-positive material in the media and granular osmiophilic material seen on electron microscopy are characteristic of Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), but not of polyarteritis nodosa.  (See References)

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C) Inflammation of the arteries, with multinucleated giant cells proliferating in the intimal layer

This answer is incorrect.

Arteries with multinucleated giant cells in the intima are characteristic of primary angiitis of the CNS, but not of polyarteritis nodosa.   (See References)

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D) Granular osmiophilic material seen on electron microscopy

This answer is incorrect.

Thickened arteries with granular, periodic acid-Schiff-positive material in the media and granular osmiophilic material seen on electron microscopy are characteristic of Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), but not of polyarteritis nodosa.  (See References)

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E) Amyloid deposition in the media of the artery

This answer is incorrect.

Arteries with amyloid deposition is characteristic of amyloid angiopathy, but not of polyarteritis nodosa.   (See References)

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References:

1. Prayson, R.A., and Goldblum, J.R. (Eds.) (2005). Neuropathology. Elsevier Churchill Livingstone, Philadelphia. (ISBN:0443066582)

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pathology
Pathology of polyarteritis nodosa
Question ID: 120707028
Question written by J. Douglas Miles, (C) 2006-2009, all rights reserved.
Created: 12/07/2007
Modified: 12/07/2007
Estimated Permutations: 600