antiepileptic medications

Topic: Pathology

Created on Saturday, September 2 2006 by

Last modified on Saturday, September 2 2006.

 
        A) Tiagabine is indicated for treatment of partial seizures.
 
        B) Levetiracetam is metabolized primarily in the liver.
 
        C) Phenytoin is the drug of first choice for patients with absence seizures only.
 
        D) Phenytoin is a known teratogen, or evidence for its teratogenicity exists.
 
        E) Tiagabine causes reduction of T-Calcium currents.
 

 

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This question was created on September 02, 2006 by .
This question was last modified on September 02, 2006.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS

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A) Tiagabine is indicated for treatment of partial seizures.

This answer is correct.

The statement, "Tiagabine is indicated for treatment of partial seizures." is true.
Tiagabine causes reduction of sodium currents, is indicated for treatment of partial seizures, is metabolized primarily in the liver, and is approved as adjunct therapy only.  (See References)

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B) Levetiracetam is metabolized primarily in the liver.

This answer is incorrect.

The statement, "Levetiracetam is metabolized primarily in the liver." is false.
Levetiracetam works via an unknown mechanism, is indicated for treatment of partial seizures, is metabolized primarily by the kidney, is approved as adjunct therapy only, is excreted in breast milk, has no known significant drug interactions, and has no known significant interactions with other AEDs.  (See References)

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C) Phenytoin is the drug of first choice for patients with absence seizures only.

This answer is incorrect.

The statement, "Phenytoin is the drug of first choice for patients with absence seizures only." is false.
Phenytoin causes reduction of sodium currents, causes increase of GABA-mediated currents, is a glutamate receptor antagonist, works via an unknown mechanism, is indicated for treatement of complex partial seizures, is indicated for treatment of partial seizures, is indicated for tonic-clonic, is metabolized primarily in the liver, induces hepatic enzymes, is excreted in breast milk, can be given as a loading dose, has been shown in comparative studies to be one of the two safest of the older AEDs, and is a drug for which the AAN recommends patients stick to one manufacturer's preparation, as evidence exists that there are differences between generic and brand name preparations.  (See References)

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D) Phenytoin is a known teratogen, or evidence for its teratogenicity exists.

This answer is incorrect.

The statement, "Phenytoin is a known teratogen, or evidence for its teratogenicity exists." is false.
Phenytoin causes reduction of sodium currents, causes increase of GABA-mediated currents, is a glutamate receptor antagonist, works via an unknown mechanism, is indicated for treatement of complex partial seizures, is indicated for treatment of partial seizures, is indicated for tonic-clonic, is metabolized primarily in the liver, induces hepatic enzymes, is excreted in breast milk, can be given as a loading dose, has been shown in comparative studies to be one of the two safest of the older AEDs, and is a drug for which the AAN recommends patients stick to one manufacturer's preparation, as evidence exists that there are differences between generic and brand name preparations.  (See References)

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E) Tiagabine causes reduction of T-Calcium currents.

This answer is incorrect.

The statement, "Tiagabine causes reduction of T-Calcium currents." is false.
Tiagabine causes reduction of sodium currents, is indicated for treatment of partial seizures, is metabolized primarily in the liver, and is approved as adjunct therapy only.  (See References)

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References:

1. Browne, T.R., & Holmes, G.L. (2004). Handbook of Epilepsy, 3rd Edition. Lippincott Williams & Wilkins, Philadelphia., Leppik, I.E. (2001). Contemporary Diagnosis and Management of the Patient with Epilepsy, 5th Edition. Handbooks in Health Care, Newtown, Pennsylvania.

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pathology
antiepileptic medications
Question ID: 540025025
Question written by . (C) FrontalCortex.com 2006-2009, all rights reserved. Created: 09/02/2006
Modified: 09/02/2006
Estimated Permutations: 0