antiepileptic medications

Topic: Pathology

Created on Saturday, September 2 2006 by

Last modified on Saturday, September 2 2006.

 
        A) Valproic acid is excreted in breast milk.
 
        B) Topiramate causes reduction of T-Calcium currents.
 
        C) Phenobarbital is a drug for which the AAN recommends patients stick to one manufacturer's preparation, as evidence exists that there are differences between generic and brand name preparations.
 
        D) Oxcarbazepine is metabolized primarily by the kidney.
 
        E) Clonazepam is metabolized primarily by the kidney.
 

 

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This question was created on September 02, 2006 by .
This question was last modified on September 02, 2006.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS

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A) Valproic acid is excreted in breast milk.

This answer is correct.

The statement, "Valproic acid is excreted in breast milk." is true.
Valproic acid causes reduction of sodium currents, causes increase of GABA-mediated currents, is indicated for treatement of complex partial seizures, is indicated for tonic-clonic, is indicated for treatment of absence seizures, is indicated for treatment of myoclonic seizures, is metabolized primarily in the liver, is a known teratogen, or evidence for its teratogenicity exists, is associated with an increased risk of spina bifida if taken during pregnancy, and is excreted in breast milk.  (See References)

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B) Topiramate causes reduction of T-Calcium currents.

This answer is incorrect.

The statement, "Topiramate causes reduction of T-Calcium currents." is false.
Topiramate causes reduction of sodium currents, causes increase of GABA-mediated currents, works via an unknown mechanism, is indicated for treatment of partial seizures, is indicated for tonic-clonic, is indicated for treatment of Lennox-Gastaut syndrome, is metabolized primarily by the kidney, and is excreted in breast milk.  (See References)

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C) Phenobarbital is a drug for which the AAN recommends patients stick to one manufacturer's preparation, as evidence exists that there are differences between generic and brand name preparations.

This answer is incorrect.

The statement, "Phenobarbital is a drug for which the AAN recommends patients stick to one manufacturer's preparation, as evidence exists that there are differences between generic and brand name preparations." is false.
Phenobarbital causes reduction of sodium currents, causes increase of GABA-mediated currents, is a glutamate receptor antagonist, works via an unknown mechanism, is indicated for treatment of partial seizures, is indicated for tonic-clonic, is metabolized primarily in the liver, induces hepatic enzymes, is a known teratogen, or evidence for its teratogenicity exists, is excreted in breast milk, and can be given as a loading dose.  (See References)

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D) Oxcarbazepine is metabolized primarily by the kidney.

This answer is incorrect.

The statement, "Oxcarbazepine is metabolized primarily by the kidney." is false.
Oxcarbazepine causes reduction of sodium currents, is indicated for treatement of complex partial seizures, is indicated for treatment of partial seizures, is indicated for treatment of partial seizures with secondary generalization, is metabolized primarily in the liver, is approved as adjunct therapy only, induces hepatic enzymes, and is excreted in breast milk.  (See References)

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E) Clonazepam is metabolized primarily by the kidney.

This answer is incorrect.

The statement, "Clonazepam is metabolized primarily by the kidney." is false.
Clonazepam causes reduction of sodium currents, causes increase of GABA-mediated currents, is indicated for treatment of absence seizures, is indicated for treatment of atypical absence seizures, is indicated for treatment of atonic seizures, is indicated for treatment of myoclonic seizures, is metabolized primarily in the liver, and is a known teratogen, or evidence for its teratogenicity exists.  (See References)

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References:

1. Browne, T.R., & Holmes, G.L. (2004). Handbook of Epilepsy, 3rd Edition. Lippincott Williams & Wilkins, Philadelphia., Leppik, I.E. (2001). Contemporary Diagnosis and Management of the Patient with Epilepsy, 5th Edition. Handbooks in Health Care, Newtown, Pennsylvania.

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pathology
antiepileptic medications
Question ID: 540025025
Question written by . (C) FrontalCortex.com 2006-2009, all rights reserved. Created: 09/02/2006
Modified: 09/02/2006
Estimated Permutations: 0