antiepileptic medications

Topic: Pathology

Created on Saturday, September 2 2006 by

Last modified on Saturday, September 2 2006.

 
        A) Clonazepam is a known teratogen, or evidence for its teratogenicity exists.
 
        B) Primidone is indicated for treatment of partial seizures.
 
        C) Lamotrigine is associated with an increased risk of spina bifida if taken during pregnancy.
 
        D) Lamotrigine is a glutamate receptor antagonist.
 
        E) Valproic acid is associated with an increased risk of spina bifida if taken during pregnancy.
 

 

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This question was created on September 02, 2006 by .
This question was last modified on September 02, 2006.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS

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A) Clonazepam is a known teratogen, or evidence for its teratogenicity exists.

This answer is incorrect.

The statement, "Clonazepam is a known teratogen, or evidence for its teratogenicity exists." is true.
Clonazepam causes reduction of sodium currents, causes increase of GABA-mediated currents, is indicated for treatment of absence seizures, is indicated for treatment of atypical absence seizures, is indicated for treatment of atonic seizures, is indicated for treatment of myoclonic seizures, is metabolized primarily in the liver, and is a known teratogen, or evidence for its teratogenicity exists.  (See References)

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B) Primidone is indicated for treatment of partial seizures.

This answer is incorrect.

The statement, "Primidone is indicated for treatment of partial seizures." is true.
Primidone causes reduction of sodium currents, causes increase of GABA-mediated currents, is a glutamate receptor antagonist, works via an unknown mechanism, is indicated for treatement of complex partial seizures, is indicated for treatment of partial seizures, is indicated for tonic-clonic, induces hepatic enzymes, is a known teratogen, or evidence for its teratogenicity exists, and is excreted in breast milk.  (See References)

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C) Lamotrigine is associated with an increased risk of spina bifida if taken during pregnancy.

This answer is correct.

The statement, "Lamotrigine is associated with an increased risk of spina bifida if taken during pregnancy." is false.
Lamotrigine causes reduction of sodium currents, causes increase of GABA-mediated currents, is a glutamate receptor antagonist, is indicated for treatment of partial seizures, is indicated for tonic-clonic, is indicated for treatment of atonic seizures, is indicated for treatment of tonic seizures, is indicated for treatment of myoclonic seizures, is indicated for treatment of Lennox-Gastaut syndrome, is metabolized primarily in the liver, and is excreted in breast milk.  (See References)

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D) Lamotrigine is a glutamate receptor antagonist.

This answer is incorrect.

The statement, "Lamotrigine is a glutamate receptor antagonist." is true.
Lamotrigine causes reduction of sodium currents, causes increase of GABA-mediated currents, is a glutamate receptor antagonist, is indicated for treatment of partial seizures, is indicated for tonic-clonic, is indicated for treatment of atonic seizures, is indicated for treatment of tonic seizures, is indicated for treatment of myoclonic seizures, is indicated for treatment of Lennox-Gastaut syndrome, is metabolized primarily in the liver, and is excreted in breast milk.  (See References)

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E) Valproic acid is associated with an increased risk of spina bifida if taken during pregnancy.

This answer is incorrect.

The statement, "Valproic acid is associated with an increased risk of spina bifida if taken during pregnancy." is true.
Valproic acid causes reduction of sodium currents, causes increase of GABA-mediated currents, is indicated for treatement of complex partial seizures, is indicated for tonic-clonic, is indicated for treatment of absence seizures, is indicated for treatment of myoclonic seizures, is metabolized primarily in the liver, is a known teratogen, or evidence for its teratogenicity exists, is associated with an increased risk of spina bifida if taken during pregnancy, and is excreted in breast milk.  (See References)

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References:

1. Browne, T.R., & Holmes, G.L. (2004). Handbook of Epilepsy, 3rd Edition. Lippincott Williams & Wilkins, Philadelphia., Leppik, I.E. (2001). Contemporary Diagnosis and Management of the Patient with Epilepsy, 5th Edition. Handbooks in Health Care, Newtown, Pennsylvania.

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pathology
antiepileptic medications
Question ID: 540025025
Question written by . (C) FrontalCortex.com 2006-2009, all rights reserved. Created: 09/02/2006
Modified: 09/02/2006
Estimated Permutations: 0