antiepileptic medications

Topic: Pathology

Created on Saturday, September 2 2006 by

Last modified on Saturday, September 2 2006.

 
        A) Tiagabine is indicated for treatment of partial seizures.
 
        B) Phenobarbital is a glutamate receptor antagonist.
 
        C) Ethosuximide has no known significant interactions with other AEDs.
 
        D) Zonisamide is metabolized primarily in the liver.
 
        E) Primidone is associated with an increased risk of spina bifida if taken during pregnancy.
 

 

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This question was created on September 02, 2006 by .
This question was last modified on September 02, 2006.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS

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A) Tiagabine is indicated for treatment of partial seizures.

This answer is incorrect.

The statement, "Tiagabine is indicated for treatment of partial seizures." is true.
Tiagabine causes reduction of sodium currents, is indicated for treatment of partial seizures, is metabolized primarily in the liver, and is approved as adjunct therapy only.  (See References)

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B) Phenobarbital is a glutamate receptor antagonist.

This answer is incorrect.

The statement, "Phenobarbital is a glutamate receptor antagonist." is true.
Phenobarbital causes reduction of sodium currents, causes increase of GABA-mediated currents, is a glutamate receptor antagonist, works via an unknown mechanism, is indicated for treatment of partial seizures, is indicated for tonic-clonic, is metabolized primarily in the liver, induces hepatic enzymes, is a known teratogen, or evidence for its teratogenicity exists, is excreted in breast milk, and can be given as a loading dose.  (See References)

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C) Ethosuximide has no known significant interactions with other AEDs.

This answer is incorrect.

The statement, "Ethosuximide has no known significant interactions with other AEDs." is true.
Ethosuximide causes reduction of T-Calcium currents, is indicated for treatment of absence seizures, is metabolized primarily in the liver, induces hepatic enzymes, has leukopenia as a relatively common side effect, has no known significant drug interactions, has no known significant interactions with other AEDs, and is the drug of first choice for patients with absence seizures only.  (See References)

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D) Zonisamide is metabolized primarily in the liver.

This answer is incorrect.

The statement, "Zonisamide is metabolized primarily in the liver." is true.
Zonisamide causes reduction of sodium currents, causes reduction of T-Calcium currents, is indicated for treatment of partial seizures, is metabolized primarily in the liver, is approved as adjunct therapy only, and is a known teratogen, or evidence for its teratogenicity exists.  (See References)

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E) Primidone is associated with an increased risk of spina bifida if taken during pregnancy.

This answer is correct.

The statement, "Primidone is associated with an increased risk of spina bifida if taken during pregnancy." is false.
Primidone causes reduction of sodium currents, causes increase of GABA-mediated currents, is a glutamate receptor antagonist, works via an unknown mechanism, is indicated for treatement of complex partial seizures, is indicated for treatment of partial seizures, is indicated for tonic-clonic, induces hepatic enzymes, is a known teratogen, or evidence for its teratogenicity exists, and is excreted in breast milk.  (See References)

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References:

1. Browne, T.R., & Holmes, G.L. (2004). Handbook of Epilepsy, 3rd Edition. Lippincott Williams & Wilkins, Philadelphia., Leppik, I.E. (2001). Contemporary Diagnosis and Management of the Patient with Epilepsy, 5th Edition. Handbooks in Health Care, Newtown, Pennsylvania.

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pathology
antiepileptic medications
Question ID: 540025025
Question written by . (C) FrontalCortex.com 2006-2009, all rights reserved. Created: 09/02/2006
Modified: 09/02/2006
Estimated Permutations: 0