antiepileptic medications

Topic: Pathology

Created on Saturday, September 2 2006 by

Last modified on Saturday, September 2 2006.

 
        A) Lamotrigine is indicated for treatment of Lennox-Gastaut syndrome.
 
        B) Phenytoin is indicated for tonic-clonic.
 
        C) Lamotrigine is indicated for tonic-clonic.
 
        D) Lamotrigine is indicated for treatment of myoclonic seizures.
 
        E) Ethosuximide has been shown in comparative studies to be one of the two safest of the older AEDs.
 

 

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This question was created on September 02, 2006 by .
This question was last modified on September 02, 2006.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS

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A) Lamotrigine is indicated for treatment of Lennox-Gastaut syndrome.

This answer is incorrect.

The statement, "Lamotrigine is indicated for treatment of Lennox-Gastaut syndrome." is true.
Lamotrigine causes reduction of sodium currents, causes increase of GABA-mediated currents, is a glutamate receptor antagonist, is indicated for treatment of partial seizures, is indicated for tonic-clonic, is indicated for treatment of atonic seizures, is indicated for treatment of tonic seizures, is indicated for treatment of myoclonic seizures, is indicated for treatment of Lennox-Gastaut syndrome, is metabolized primarily in the liver, and is excreted in breast milk.  (See References)

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B) Phenytoin is indicated for tonic-clonic.

This answer is incorrect.

The statement, "Phenytoin is indicated for tonic-clonic." is true.
Phenytoin causes reduction of sodium currents, causes increase of GABA-mediated currents, is a glutamate receptor antagonist, works via an unknown mechanism, is indicated for treatement of complex partial seizures, is indicated for treatment of partial seizures, is indicated for tonic-clonic, is metabolized primarily in the liver, induces hepatic enzymes, is excreted in breast milk, can be given as a loading dose, has been shown in comparative studies to be one of the two safest of the older AEDs, and is a drug for which the AAN recommends patients stick to one manufacturer's preparation, as evidence exists that there are differences between generic and brand name preparations.  (See References)

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C) Lamotrigine is indicated for tonic-clonic.

This answer is incorrect.

The statement, "Lamotrigine is indicated for tonic-clonic." is true.
Lamotrigine causes reduction of sodium currents, causes increase of GABA-mediated currents, is a glutamate receptor antagonist, is indicated for treatment of partial seizures, is indicated for tonic-clonic, is indicated for treatment of atonic seizures, is indicated for treatment of tonic seizures, is indicated for treatment of myoclonic seizures, is indicated for treatment of Lennox-Gastaut syndrome, is metabolized primarily in the liver, and is excreted in breast milk.  (See References)

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D) Lamotrigine is indicated for treatment of myoclonic seizures.

This answer is incorrect.

The statement, "Lamotrigine is indicated for treatment of myoclonic seizures." is true.
Lamotrigine causes reduction of sodium currents, causes increase of GABA-mediated currents, is a glutamate receptor antagonist, is indicated for treatment of partial seizures, is indicated for tonic-clonic, is indicated for treatment of atonic seizures, is indicated for treatment of tonic seizures, is indicated for treatment of myoclonic seizures, is indicated for treatment of Lennox-Gastaut syndrome, is metabolized primarily in the liver, and is excreted in breast milk.  (See References)

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E) Ethosuximide has been shown in comparative studies to be one of the two safest of the older AEDs.

This answer is correct.

The statement, "Ethosuximide has been shown in comparative studies to be one of the two safest of the older AEDs." is false.
Ethosuximide causes reduction of T-Calcium currents, is indicated for treatment of absence seizures, is metabolized primarily in the liver, induces hepatic enzymes, has leukopenia as a relatively common side effect, has no known significant drug interactions, has no known significant interactions with other AEDs, and is the drug of first choice for patients with absence seizures only.  (See References)

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References:

1. Browne, T.R., & Holmes, G.L. (2004). Handbook of Epilepsy, 3rd Edition. Lippincott Williams & Wilkins, Philadelphia., Leppik, I.E. (2001). Contemporary Diagnosis and Management of the Patient with Epilepsy, 5th Edition. Handbooks in Health Care, Newtown, Pennsylvania.

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pathology
antiepileptic medications
Question ID: 540025025
Question written by . (C) FrontalCortex.com 2006-2009, all rights reserved. Created: 09/02/2006
Modified: 09/02/2006
Estimated Permutations: 0