antiepileptic medications

Topic: Pathology

Created on Saturday, September 2 2006 by

Last modified on Saturday, September 2 2006.

 
        A) Gabapentin causes increase of GABA-mediated currents.
 
        B) Lamotrigine is a drug for which the AAN recommends patients stick to one manufacturer's preparation, as evidence exists that there are differences between generic and brand name preparations.
 
        C) Oxcarbazepine has no known significant drug interactions.
 
        D) Clonazepam has no known significant interactions with other AEDs.
 
        E) Ethosuximide is a drug for which the AAN recommends patients stick to one manufacturer's preparation, as evidence exists that there are differences between generic and brand name preparations.
 

 

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This question was created on September 02, 2006 by .
This question was last modified on September 02, 2006.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS

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A) Gabapentin causes increase of GABA-mediated currents.

This answer is correct.

The statement, "Gabapentin causes increase of GABA-mediated currents." is true.
Gabapentin causes increase of GABA-mediated currents, is a glutamate receptor antagonist, is indicated for treatment of partial seizures, is indicated for tonic-clonic, is metabolized primarily by the kidney, is approved as adjunct therapy only, is excreted in breast milk, and has no known significant interactions with other AEDs.  (See References)

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B) Lamotrigine is a drug for which the AAN recommends patients stick to one manufacturer's preparation, as evidence exists that there are differences between generic and brand name preparations.

This answer is incorrect.

The statement, "Lamotrigine is a drug for which the AAN recommends patients stick to one manufacturer's preparation, as evidence exists that there are differences between generic and brand name preparations." is false.
Lamotrigine causes reduction of sodium currents, causes increase of GABA-mediated currents, is a glutamate receptor antagonist, is indicated for treatment of partial seizures, is indicated for tonic-clonic, is indicated for treatment of atonic seizures, is indicated for treatment of tonic seizures, is indicated for treatment of myoclonic seizures, is indicated for treatment of Lennox-Gastaut syndrome, is metabolized primarily in the liver, and is excreted in breast milk.  (See References)

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C) Oxcarbazepine has no known significant drug interactions.

This answer is incorrect.

The statement, "Oxcarbazepine has no known significant drug interactions." is false.
Oxcarbazepine causes reduction of sodium currents, is indicated for treatement of complex partial seizures, is indicated for treatment of partial seizures, is indicated for treatment of partial seizures with secondary generalization, is metabolized primarily in the liver, is approved as adjunct therapy only, induces hepatic enzymes, and is excreted in breast milk.  (See References)

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D) Clonazepam has no known significant interactions with other AEDs.

This answer is incorrect.

The statement, "Clonazepam has no known significant interactions with other AEDs." is false.
Clonazepam causes reduction of sodium currents, causes increase of GABA-mediated currents, is indicated for treatment of absence seizures, is indicated for treatment of atypical absence seizures, is indicated for treatment of atonic seizures, is indicated for treatment of myoclonic seizures, is metabolized primarily in the liver, and is a known teratogen, or evidence for its teratogenicity exists.  (See References)

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E) Ethosuximide is a drug for which the AAN recommends patients stick to one manufacturer's preparation, as evidence exists that there are differences between generic and brand name preparations.

This answer is incorrect.

The statement, "Ethosuximide is a drug for which the AAN recommends patients stick to one manufacturer's preparation, as evidence exists that there are differences between generic and brand name preparations." is false.
Ethosuximide causes reduction of T-Calcium currents, is indicated for treatment of absence seizures, is metabolized primarily in the liver, induces hepatic enzymes, has leukopenia as a relatively common side effect, has no known significant drug interactions, has no known significant interactions with other AEDs, and is the drug of first choice for patients with absence seizures only.  (See References)

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References:

1. Browne, T.R., & Holmes, G.L. (2004). Handbook of Epilepsy, 3rd Edition. Lippincott Williams & Wilkins, Philadelphia., Leppik, I.E. (2001). Contemporary Diagnosis and Management of the Patient with Epilepsy, 5th Edition. Handbooks in Health Care, Newtown, Pennsylvania.

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pathology
antiepileptic medications
Question ID: 540025025
Question written by . (C) FrontalCortex.com 2006-2009, all rights reserved. Created: 09/02/2006
Modified: 09/02/2006
Estimated Permutations: 0