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Neuromuscular 01

Topic: Pathology

Created on Sunday, February 8 2009 by gliageek

Last modified on Sunday, February 8 2009.


Ultrastructurally, these cytoplasmic inclusions most closely resemble:

 
        A) Sarcoplasmic reticulin
 
        B) Myosin filaments
 
        C) Actin filaments
 
        D) Z-bands
 
        E) Mitochondria
 

 


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This question was created on February 08, 2009 by gliageek.
This question was last modified on February 08, 2009.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS




A) sarcoplasmic reticulin

This answer is incorrect.


Tubular aggregates reseble sarcoplasmic reticulin, and appear as bright red subsarcolemmal aggregates on trichrome staining  (See References)

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B) myosin filaments

This answer is incorrect.


Tubulofilamentous inclusions (characteristic of inclusion body myositis) are even somewhat larger than the thick myosin filaments  (See References)

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C) actin filaments

This answer is incorrect.


Amyloid filaments are 8-9nm in diameter, and hence may resemble thin actin filaments  (See References)

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D) Z-bands

This answer is correct.


Nemaline rods appear to composed predominantly of alpha-actinin, and resemble z-bands  (See References)

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E) mitochondria

This answer is incorrect.


Mitochondria appear redder on trichrome, and are preferentially seen in subsarcolemmal locations  (See References)

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References:

1. Prayson, R.A., and Goldblum, J.R. (Eds.) (2005). Neuropathology. Elsevier Churchill Livingstone, Philadelphia. (ISBN:0443066582)Advertising:
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pathology
Neuromuscular 01
Question ID: 020809068
Question written by gliageek. (C) FrontalCortex.com 2006-2009, all rights reserved. Created: 02/08/2009
Modified: 02/08/2009
Estimated Permutations: 120

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