Myelin 03

Topic: Pathology

Created on Sunday, February 15 2009 by gliageek

Last modified on Sunday, February 15 2009.

 
        A) Deficiency in sphingomyelinase
 
        B) Accumulation of galactosylceramide
 
        C) Accumulation of globotriaosylceramide
 
        D) Accumulation of sulfatide
 
        E) Accumulation of spingolipid ceramide
 

 

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This question was created on February 15, 2009 by gliageek.
This question was last modified on February 15, 2009.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS

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A) Deficiency in sphingomyelinase

This answer is incorrect.

Foam cell infiltration in PNS and viscera (Niemann-Pick disease)  (See References)

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B) Accumulation of galactosylceramide

This answer is correct.

Deficiency of galatocerebroside B-galactosidase results in the accumulation of the toxic intermediate galactosylceramide ("psychosine") via an alternate catabolic pathway  (See References)

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C) Accumulation of globotriaosylceramide

This answer is incorrect.

Fabry's disease, with accumulation of globotriaosylceramide within endothelial cellsA  (See References)

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D) Accumulation of sulfatide

This answer is incorrect.

Metachromatic leukodystrophy  (See References)

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E) Accumulation of spingolipid ceramide

This answer is incorrect.

Spingolipid ceramide may accumulate in Schwann cells in Farber disease  (See References)

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References:

1. Love, S., Louis, D.N., and Ellison, D.W. (2008). Greenfield's Neuropathology, 8th Edition. Oxford University Press, USA (ISBN:0340906820)

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pathology
Myelin 03
Question ID: 021509085
Question written by gliageek. (C) FrontalCortex.com 2006-2009, all rights reserved. Created: 02/15/2009
Modified: 02/15/2009
Estimated Permutations: 120