FrontalCortex, Inc. is a non-profit corporation dedicated to neurology education.

Neurocutaneous 05

Topic: Pathology

Created on Monday, February 16 2009 by gliageek

Last modified on Monday, February 16 2009.


Courtesy of Dr. Mark Cohen
This 4 year old boy, noted to have multiple skin lesions, may have a germline mutation in which of the following genes?

 
        A) TSC2
 
        B) PTEN
 
        C) APC
 
        D) PTCH
 
        E) TP53
 

 


Back to the question = Go back to the top of the page.
See another question like this one = Reload a different version of this question ().
Click here for a random question = Load a random question from the database.
Clone this question = Use this question as a template to create a totally NEW question.
Rate this question = Enter detailed rating for this question!
Average user rating for this question = 3.5 = How users like you have rated this question.
This question was created on February 16, 2009 by gliageek.
This question was last modified on February 16, 2009.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS




A) TSC2

This answer is incorrect.


TS does not include PNETs  (See References)

Back to the questionSee another question like this oneClick here for a random questionClone this question Rate this questionAverage user rating for this question = 3.5
Please log in if you want to rate questions.

 

 

 

 

 

 

 

 

 




B) PTEN

This answer is incorrect.


Multiple tricholemmomas are seen in Cowden disease, but the cerebellar lesion in dysplastic gangliocytoma  (See References)

Back to the questionSee another question like this oneClick here for a random questionClone this question Rate this questionAverage user rating for this question = 3.5
Please log in if you want to rate questions.

 

 

 

 

 

 

 

 

 




C) APC

This answer is incorrect.


Turcot syndrome includes MB, but not skin lesions  (See References)

Back to the questionSee another question like this oneClick here for a random questionClone this question Rate this questionAverage user rating for this question = 3.5
Please log in if you want to rate questions.

 

 

 

 

 

 

 

 

 




D) PTCH

This answer is correct.


Desmoplastic medulloblastoma in a child under age 5 should raise the possibility of Gorlin syndrome  (See References)

Back to the questionSee another question like this oneClick here for a random questionClone this question Rate this questionAverage user rating for this question = 3.5
Please log in if you want to rate questions.

 

 

 

 

 

 

 

 

 




E) TP53

This answer is incorrect.


Li-Fraumeni generally does not include skin lesions  (See References)

Back to the questionSee another question like this oneClick here for a random questionClone this question Rate this questionAverage user rating for this question = 3.5
Please log in if you want to rate questions.

 

 

 

 

References:

1. Love, S., Louis, D.N., and Ellison, D.W. (2008). Greenfield's Neuropathology, 8th Edition. Oxford University Press, USA (ISBN:0340906820)Advertising:
Back to the questionSee another question like this oneClick here for a random questionClone this question Rate this questionAverage user rating for this question = 3.5
Please log in if you want to rate questions.

 

FrontalCortex.com -- Neurology Review Questions -- Neurology Boards -- Board Review -- Residency Inservice Training Exam -- RITE Exam Review
pathology
Neurocutaneous 05
Question ID: 021609115
Question written by gliageek. (C) FrontalCortex.com 2006-2009, all rights reserved. Created: 02/16/2009
Modified: 02/16/2009
Estimated Permutations: 120

User Comments About This Question:

0 user entries
Please log in if you'd like to add a comment.