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Neurodegen 07

Topic: Pathology

Created on Monday, February 16 2009 by gliageek

Last modified on Monday, February 16 2009.

Courtesy of Dr. Mark Cohen

This tau negative, ubiquitin stained section of dentate gyrus suggests that, in addition to dementia, this patient may have manifest which of the following signs?

A) Chorea and ballismus

B) Bradkinesia and tremor

C) Weakness and spasticity

D) Semantic dementia

E) Aphasia

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This question was created on February 16, 2009 by gliageek.
This question was last modified on February 16, 2009.

ANSWERS AND EXPLANATIONS

A) Chorea and ballismus

This answer is incorrect.

Huntington disease does not show cytoplasmic inclusions in dentate gyrus (See References)


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B) Bradkinesia and tremor

This answer is incorrect.

Seen in Lewy body dementia (synucleinopathy), which does not involve dentate gyrus (See References)


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C) Weakness and spasticity

This answer is correct.

FTLD-U/FTLD-TDP43 is associated with motor neuron like disease (See References)


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D) Semantic dementia

This answer is incorrect.

Generally seen in FTLD-tau (See References)


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E) Aphasia

This answer is incorrect.

Generally seen in FTLD-tau (See References)


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References:

1. Love, S., Louis, D.N., and Ellison, D.W. (2008). Greenfield's Neuropathology, 8th Edition. Oxford University Press, USA (ISBN:0340906820)

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pathology
Neurodegen 07
Question ID: 021609162
Question written by gliageek. (C) FrontalCortex.com 2006-2009, all rights reserved. Created: 02/16/2009
Modified: 02/16/2009
Estimated Permutations: 120