Dementia 02
Topic: Imaging
Created on Thursday, February 22 2007 by jdmiles
Last modified on Thursday, February 22 2007.
A 74 year-old male presents to your office accompanied by his nephew, who provides most of the history.
The nephew states that for quite some time now, the patient has had dramatic fluctuations in his level of arousal, has complained of rigidity, developed a tremor, lost his balance a few times, has had more and more trouble remembering things, and occasionally mentions that he is seeing people in the room that nobody else sees.
Which of the following pathology findings is MOST characteristic of this patient's disease?
A) Eosinophilic nuclear inclusions B) Neuronal aggregates C) Neurofibrillary tangles, D) Inclusions comprised primarily of American cheese E) Eosinophilic cytoplasmic inclusions
This question was created on February 22, 2007 by jdmiles.
This question was last modified on February 22, 2007.
ANSWERS AND EXPLANATIONS
A) eosinophilic nuclear inclusions
This answer is incorrect.
This patient's history is consistent with dementia with Lewy bodies (DLB). Patients with DLB develop Parkinsonian symptoms and dementia symptoms at approximately the same time. Other key clinical features include recurrent visual hallucinations and fluctuations in mental status. Lewy bodies are eosinophilic cytoplasmic inclusions. (
See References)
B) neuronal aggregates
This answer is incorrect.
This patient's history is consistent with dementia with Lewy bodies (DLB). Patients with DLB develop Parkinsonian symptoms and dementia symptoms at approximately the same time. Other key clinical features include recurrent visual hallucinations and fluctuations in mental status. Neuronal aggregates and Bunina bodies are seen in amyotrophic lateral sclerosis. (
See References)
C) neurofibrillary tangles,
This answer is incorrect.
This patient's history is consistent with dementia with Lewy bodies (DLB). Patients with DLB develop Parkinsonian symptoms and dementia symptoms at approximately the same time. Other key clinical features include recurrent visual hallucinations and fluctuations in mental status. Neurofibrillary tangles tend to be sparse in DLB. Neurofibrillary are more commonly associated with Alzheimer disease. (
See References)
D) inclusions comprised primarily of American cheese
This answer is incorrect.
This patient's history is consistent with dementia with Lewy bodies (DLB). Patients with DLB develop Parkinsonian symptoms and dementia symptoms at approximately the same time. Other key clinical features include recurrent visual hallucinations and fluctuations in mental status. Lewy bodies are eosinophilic cytoplasmic inclusions comprised mainly of alpha-synuclein, and contain little or no cheese of any kind. (
See References)
E) eosinophilic cytoplasmic inclusions
This answer is correct.
This patient's history is consistent with dementia with Lewy bodies (DLB). Patients with DLB develop Parkinsonian symptoms and dementia symptoms at approximately the same time. Other key clinical features include recurrent visual hallucinations and fluctuations in mental status. Lewy bodies are eosinophilic cytoplasmic inclusions which contain alpha-synuclein. (
See References)
References:
1. Victor, M., and Ropper, A.H. (2001). Adams and Victor's Principles of Neurology, 7th Edition. McGraw-Hill, New York. | |
2. DeKosky, S.T., Kaufer, D.I., and Lopez, O.L. (2004). The Dementias. In Bradley, W.G., Daroff, R.B., Fenichel, G.M., and Jankovic, J. (Eds.). Neurology in Clinical Practice, 4th Edition. Butterworth Heinemann, Philadelphia. Pp. 1901-1951 | |
3. Prayson, R.A., and Goldblum, J.R. (Eds.) (2005). Neuropathology. Elsevier, Philadelphia. | |
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imaging
Dementia 02
Question ID: 02220701
Question written by J. Douglas Miles, (C) 2006-2009, all rights reserved.
Created: 02/22/2007
Modified: 02/22/2007
Estimated Permutations: 0