DIGOA

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DIGOA

Last updated on Wednesday, September 10 2008 by jdmiles

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Desmoplastic infantile astrocytoma, H&E stain x100
Initially described as superficial cerebral astrocytomas attached to the dura in infancy, it is now recognized that D. superficial desmoplastic gliomas may or may not demonstrate divergent differentiation, but still share a common presentation and favorable prognosis.

Desmoplastic infantile astrocytoma, H&E stain x400
At this higher magnification, astrocytic differentiation can be appreciated among the spindle cells (also astrocytic).

Desmoplastic infantile ganglioglioma, H&E stain x100
Sharing the spindle cell/desmoplastic milieu with the desmoplastic infantile astrocytoma, this desmoplastic infantile ganglioma demonstrates similar presentation as a large, often multi-lobe, multicystic mass in very early childhood, as well as the usually very favorable postoperative outcome.

Desmoplastic infantile ganglioglioma, H&E stain x400
At this higher magnification, several cells demonstrating prominent nucleoli characteristic of ganglion cell differentiation can be identified.