NADH is a marker for oxidative activity. Histochemical staining for NADH can therefore give an indication of the relative oxitadive activity of a structure. Among other things, NDAH staining can be used to differentiate Type I from Type II mucle fibers, or show the presence of central cores.
Related images:
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| NADH - Example of pathological findings This is an NADH stain of skeletal muscle from a patient with central core diseae (CCD). The defining feature of CCD are cores, which appear as pale blobs on stains for oxidative activity, like NADH or COX. The cores are regions which have no mitochondria,... |
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| NADH - Normal Example This is a slice of normal muscle, stained with a stain specific for NADH. Note the mosaic pattern of light and dark fibers, and the polygonal look of the fibers. |
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| NADH - Example of pathological findings Target fibers in skeletal muscle, stained for NADH. |
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