Agents that Affect Cholinergic Synapses - Super Quiz 01

Topic: Pharmacology

Created on Saturday, October 18 2008 by jdmiles

Last modified on Saturday, October 18 2008.

 
        A) Scopolamine is a selective nicotinic receptor antagonist
 
        B) Vesamicol inhibits acetylcholine uptake in presynaptic vesicles
 
        C) Botulinum toxin is a selective muscarinic receptor antagonist
 
        D) Black widow spider venom inhibits acetylcholine release from vesicles
 
        E) Organophosphates are selective nicotinic receptor agonists
 

 

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This question was created on October 18, 2008 by jdmiles.
This question was last modified on October 18, 2008.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS

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A) scopolamine is a selective nicotinic receptor antagonist

This answer is incorrect.

Scopolamine is a muscarinic receptor antagonist  (See References)

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B) vesamicol inhibits acetylcholine uptake in presynaptic vesicles

This answer is correct.

Vesamicol inhibits acetylcholine uptake in presynaptic vesicles  (See References)

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C) botulinum toxin is a selective muscarinic receptor antagonist

This answer is incorrect.

Botulinum toxin inhibits acetylcholine release from vesicles  (See References)

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D) black widow spider venom inhibits acetylcholine release from vesicles

This answer is incorrect.

Black widow spider venom promotes mass release of acetylcholine vesicles  (See References)

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E) organophosphates are selective nicotinic receptor agonists

This answer is incorrect.

Organophosphates irreversibly inhibit acetylcholinesterase  (See References)

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References:

1. Zygmunt L. Kruk and Christopher J. Pycock. . London ; Chapman and Hall, 1991. (ISBN:412361108)	Advertising:
2. Gorio, A., Hurlbut, W.P., and Ceccarelli, B. (1978). "Acetylcholine compartments in mouse diaphragm. Comparison of the effects of black widow spider venom, electrical stimulation, and high concentrations of potassium." J Cell Biol, 78(3) 716-33. (PMID:701357)
3. Salin-Pascual, R.J., and Jimenez-Anguiano, A. (1995). "Vesamicol, an acetylcholine uptake blocker in presynaptic vesicles, suppresses rapid eye movement (REM) sleep in the rat." Psychopharmacology (Berl), 121(4) 485-7. (PMID:8619013)
4. McCann, C.M., Bracamontes, J., Steinbach, J.H., and Sanes, J.R. (2006). "The cholinergic antagonist alpha-bungarotoxin also binds and blocks a subset of GABA receptors." Proc Natl Acad Sci U S A, 103(13) 5149-54. (PMID:16549768)
5. Prasarnpun, S., Walsh, J., and Harris, J.B. (2004). "Beta-bungarotoxin-induced depletion of synaptic vesicles at the mammalian neuromuscular junction." Neuropharmacology, 47(2) 304-14. (PMID:15223309)

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pharmacology
Agents that Affect Cholinergic Synapses - Super Quiz 01
Question ID: 10180801
Question written by J. Douglas Miles, (C) 2006-2009, all rights reserved.
Created: 10/18/2008
Modified: 10/18/2008
Estimated Permutations: 41038176000