Pathology of giant cell arteritis

Topic: Pathology

Created on Friday, December 7 2007 by jdmiles

Last modified on Friday, December 7 2007.

 
        A) Granular osmiophilic material seen on electron microscopy
 
        B) Thickened arteries with granular, periodic acid-Schiff-positive material in the media
 
        C) Lymphocytic infiltration of the arteries
 
        D) Neutrophilic inflammation of the arteries
 
        E) Amyloid deposition in the media of the artery
 

 

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This question was created on December 07, 2007 by jdmiles.
This question was last modified on December 07, 2007.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS

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A) Granular osmiophilic material seen on electron microscopy

This answer is incorrect.

Thickened arteries with granular, periodic acid-Schiff-positive material in the media and granular osmiophilic material seen on electron microscopy are characteristic of Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), but not of giant cell arteritis.  (See References)

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B) Thickened arteries with granular, periodic acid-Schiff-positive material in the media

This answer is incorrect.

Thickened arteries with granular, periodic acid-Schiff-positive material in the media and granular osmiophilic material seen on electron microscopy are characteristic of Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), but not of giant cell arteritis.  (See References)

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C) Lymphocytic infiltration of the arteries

This answer is correct.

Arteries with mononuclear infiltration are characteristic of giant cell arteritis.  (See References)

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D) Neutrophilic inflammation of the arteries

This answer is incorrect.

Neutrophilic inflammation of the arteries is the characteristic pathologic finding in polyarteritis nodosa, but not of giant cell arteritis.  (See References)

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E) Amyloid deposition in the media of the artery

This answer is incorrect.

Arteries with amyloid deposition is characteristic of amyloid angiopathy, but not of giant cell arteritis.  (See References)

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References:

1. Prayson, R.A., and Goldblum, J.R. (Eds.) (2005). Neuropathology. Elsevier Churchill Livingstone, Philadelphia. (ISBN:0443066582)

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pathology
Pathology of giant cell arteritis
Question ID: 120707038
Question written by J. Douglas Miles, (C) 2006-2009, all rights reserved.
Created: 12/07/2007
Modified: 12/07/2007
Estimated Permutations: 600