FrontalCortex, Inc. is a non-profit corporation dedicated to neurology education.

Pathology of giant cell arteritis

Topic: Pathology

Created on Friday, December 7 2007 by jdmiles

Last modified on Friday, December 7 2007.

Which of the following pathological findings is most characteristic of giant cell arteritis?

 
        A) Lymphocytic infiltration of the arteries
 
        B) Neutrophilic inflammation of the arteries
 
        C) Inflammation of the arteries, with multinucleated giant cells proliferating in the intimal layer
 
        D) Granular osmiophilic material seen on electron microscopy
 
        E) Thickened arteries with granular, periodic acid-Schiff-positive material in the media
 

 


Back to the question = Go back to the top of the page.
See another question like this one = Reload a different version of this question ().
Click here for a random question = Load a random question from the database.
Clone this question = Use this question as a template to create a totally NEW question.
Rate this question = Enter detailed rating for this question!
Average user rating for this question = 3 = How users like you have rated this question.
This question was created on December 07, 2007 by jdmiles.
This question was last modified on December 07, 2007.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS




A) Lymphocytic infiltration of the arteries

This answer is correct.


Arteries with mononuclear infiltration are characteristic of giant cell arteritis.  (See References)

Back to the questionSee another question like this oneClick here for a random questionClone this question Rate this questionAverage user rating for this question = 3
Please log in if you want to rate questions.

 

 

 

 

 

 

 

 

 




B) Neutrophilic inflammation of the arteries

This answer is incorrect.


Neutrophilic inflammation of the arteries is the characteristic pathologic finding in polyarteritis nodosa, but not of giant cell arteritis.  (See References)

Back to the questionSee another question like this oneClick here for a random questionClone this question Rate this questionAverage user rating for this question = 3
Please log in if you want to rate questions.

 

 

 

 

 

 

 

 

 




C) Inflammation of the arteries, with multinucleated giant cells proliferating in the intimal layer

This answer is incorrect.


Arteries with multinucleated giant cells in the intima are characteristic of primary angiitis of the CNS, but not of giant cell arteritis.  (See References)

Back to the questionSee another question like this oneClick here for a random questionClone this question Rate this questionAverage user rating for this question = 3
Please log in if you want to rate questions.

 

 

 

 

 

 

 

 

 




D) Granular osmiophilic material seen on electron microscopy

This answer is incorrect.


Thickened arteries with granular, periodic acid-Schiff-positive material in the media and granular osmiophilic material seen on electron microscopy are characteristic of Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), but not of giant cell arteritis.  (See References)

Back to the questionSee another question like this oneClick here for a random questionClone this question Rate this questionAverage user rating for this question = 3
Please log in if you want to rate questions.

 

 

 

 

 

 

 

 

 




E) Thickened arteries with granular, periodic acid-Schiff-positive material in the media

This answer is incorrect.


Thickened arteries with granular, periodic acid-Schiff-positive material in the media and granular osmiophilic material seen on electron microscopy are characteristic of Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), but not of giant cell arteritis.  (See References)

Back to the questionSee another question like this oneClick here for a random questionClone this question Rate this questionAverage user rating for this question = 3
Please log in if you want to rate questions.

 

 

 

 

References:

1. Prayson, R.A., and Goldblum, J.R. (Eds.) (2005). Neuropathology. Elsevier Churchill Livingstone, Philadelphia. (ISBN:0443066582) Advertising:
Back to the questionSee another question like this oneClick here for a random questionClone this question Rate this questionAverage user rating for this question = 3
Please log in if you want to rate questions.

 

FrontalCortex.com -- Neurology Review Questions -- Neurology Boards -- Board Review -- Residency Inservice Training Exam -- RITE Exam Review
pathology
Pathology of giant cell arteritis
Question ID: 120707038
Question written by J. Douglas Miles, (C) 2006-2009, all rights reserved.
Created: 12/07/2007
Modified: 12/07/2007
Estimated Permutations: 600

User Comments About This Question:

0 user entries
Please log in if you'd like to add a comment.