Interactions of AEDs 01

Topic: Pharmacology

Created on Monday, December 24 2007 by jdmiles

Last modified on Monday, December 24 2007.

 
        A) A patient taking both sertraline and lamotrigine would need a higher dose of lamotrigine than he would if he were not taking sertraline
 
        B) A patient taking both carbamazepine and lamotrigine will need a lower dose of lamotrigine than he would if he were not on carbamazepine
 
        C) Carbamazepine prolongs the half-life of lamotrigine
 
        D) A patient taking both phenytoin and lamotrigine will need a lower dose of lamotrigine than he would if he were not on phenytoin
 
        E) Phenobarbital reduces the half-life of lamotrigine
 

 

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This question was created on December 24, 2007 by jdmiles.
This question was last modified on December 24, 2007.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS

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A) A patient taking both sertraline and lamotrigine would need a higher dose of lamotrigine than he would if he were not taking sertraline

This answer is incorrect.

Sertraline prolongs the half-life of lamotrigine. This means that a patient taking both sertraline and lamotrigine will need a LOWER dose of lamotrigine than he would if he were not on sertraline.  (See References)

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B) A patient taking both carbamazepine and lamotrigine will need a lower dose of lamotrigine than he would if he were not on carbamazepine

This answer is incorrect.

Carbamazepine reduces the half-life of lamotrigine. This means that a patient taking both carbamazepine and lamotrigine will need a HIGHER dose of lamotrigine than he would if he were not on carbamazepine.   (See References)

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C) carbamazepine prolongs the half-life of lamotrigine

This answer is incorrect.

Carbamazepine reduces the half-life of lamotrigine. This means that a patient taking both carbamazepine and lamotrigine will need a HIGHER dose of lamotrigine than he would if he were not on carbamazepine.   (See References)

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D) A patient taking both phenytoin and lamotrigine will need a lower dose of lamotrigine than he would if he were not on phenytoin

This answer is incorrect.

Phenytoin reduces the half-life of lamotrigine. This means that a patient taking both phenytoin and lamotrigine will need a HIGHER dose of lamotrigine than he would if he were not on phenytoin.   (See References)

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E) phenobarbital reduces the half-life of lamotrigine

This answer is correct.

Phenobarbital reduces the half-life of lamotrigine. This means that a patient taking both phenobarbital and lamotrigine will need a HIGHER dose of lamotrigine than he would if he were not on phenobarbital.   (See References)

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References:

1. Browne, T.R., & Holmes, G.L. (2004). Handbook of Epilepsy, 3rd Edition. Lippincott Williams & Wilkins, Philadelphia. (ISBN:0781743524)

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pharmacology
Interactions of AEDs 01
Question ID: 122307205
Question written by J. Douglas Miles, (C) 2006-2009, all rights reserved.
Created: 12/24/2007
Modified: 12/24/2007
Estimated Permutations: 252000