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Interactions of AEDs 01

Topic: Pharmacology

Created on Monday, December 24 2007 by jdmiles

Last modified on Monday, December 24 2007.

You have a patient with epilepsy. He is already on one antiepileptic agent, and you are about to add lamotrigine. Which of the following statements about the interactions of lamotrigine and other medications are true?

 
        A) A patient taking both sertraline and lamotrigine would need a higher dose of lamotrigine than he would if he were not taking sertraline
 
        B) Phenytoin prolongs the half-life of lamotrigine
 
        C) Sertraline reduces the half-life of lamotrigine
 
        D) A patient taking both phenobarbital and lamotrigine will need a higher dose of lamotrigine than he would if he were not on phenobarbital
 
        E) A patient taking both phenytoin and lamotrigine will need a lower dose of lamotrigine than he would if he were not on phenytoin
 

 


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This question was created on December 24, 2007 by jdmiles.
This question was last modified on December 24, 2007.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS




A) A patient taking both sertraline and lamotrigine would need a higher dose of lamotrigine than he would if he were not taking sertraline

This answer is incorrect.


Sertraline prolongs the half-life of lamotrigine. This means that a patient taking both sertraline and lamotrigine will need a LOWER dose of lamotrigine than he would if he were not on sertraline.  (See References)

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B) phenytoin prolongs the half-life of lamotrigine

This answer is incorrect.


Phenytoin reduces the half-life of lamotrigine. This means that a patient taking both phenytoin and lamotrigine will need a HIGHER dose of lamotrigine than he would if he were not on phenytoin.   (See References)

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C) sertraline reduces the half-life of lamotrigine

This answer is incorrect.


Sertraline prolongs the half-life of lamotrigine. This means that a patient taking both sertraline and lamotrigine will need a LOWER dose of lamotrigine than he would if he were not on sertraline.  (See References)

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D) A patient taking both phenobarbital and lamotrigine will need a higher dose of lamotrigine than he would if he were not on phenobarbital

This answer is correct.


Phenobarbital reduces the half-life of lamotrigine. This means that a patient taking both phenobarbital and lamotrigine will need a HIGHER dose of lamotrigine than he would if he were not on phenobarbital.   (See References)

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E) A patient taking both phenytoin and lamotrigine will need a lower dose of lamotrigine than he would if he were not on phenytoin

This answer is incorrect.


Phenytoin reduces the half-life of lamotrigine. This means that a patient taking both phenytoin and lamotrigine will need a HIGHER dose of lamotrigine than he would if he were not on phenytoin.   (See References)

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References:

1. Browne, T.R., & Holmes, G.L. (2004). Handbook of Epilepsy, 3rd Edition. Lippincott Williams & Wilkins, Philadelphia. (ISBN:0781743524) Advertising:
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pharmacology
Interactions of AEDs 01
Question ID: 122307205
Question written by J. Douglas Miles, (C) 2006-2009, all rights reserved.
Created: 12/24/2007
Modified: 12/24/2007
Estimated Permutations: 252000

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