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Interactions of AEDs 01

Topic: Pharmacology

Created on Monday, December 24 2007 by jdmiles

Last modified on Monday, December 24 2007.

You have a patient with epilepsy. He is already on one antiepileptic agent, and you are about to add lamotrigine. Which of the following statements about the interactions of lamotrigine and other medications are true?

 
        A) Phenobarbital reduces the half-life of lamotrigine
 
        B) Carbamazepine prolongs the half-life of lamotrigine
 
        C) Phenytoin prolongs the half-life of lamotrigine
 
        D) Phenobarbital prolongs the half-life of lamotrigine
 
        E) Valproic acid reduces the half-life of lamotrigine
 

 


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This question was created on December 24, 2007 by jdmiles.
This question was last modified on December 24, 2007.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

ANSWERS AND EXPLANATIONS




A) phenobarbital reduces the half-life of lamotrigine

This answer is correct.


Phenobarbital reduces the half-life of lamotrigine. This means that a patient taking both phenobarbital and lamotrigine will need a HIGHER dose of lamotrigine than he would if he were not on phenobarbital.   (See References)

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B) carbamazepine prolongs the half-life of lamotrigine

This answer is incorrect.


Carbamazepine reduces the half-life of lamotrigine. This means that a patient taking both carbamazepine and lamotrigine will need a HIGHER dose of lamotrigine than he would if he were not on carbamazepine.   (See References)

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C) phenytoin prolongs the half-life of lamotrigine

This answer is incorrect.


Phenytoin reduces the half-life of lamotrigine. This means that a patient taking both phenytoin and lamotrigine will need a HIGHER dose of lamotrigine than he would if he were not on phenytoin.   (See References)

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D) phenobarbital prolongs the half-life of lamotrigine

This answer is incorrect.


Phenobarbital reduces the half-life of lamotrigine. This means that a patient taking both phenobarbital and lamotrigine will need a HIGHER dose of lamotrigine than he would if he were not on phenobarbital.   (See References)

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E) valproic acid reduces the half-life of lamotrigine

This answer is incorrect.


Valproic acid prolongs the half-life of lamotrigine. This means that a patient taking both valproic acid and lamotrigine will need a LOWER dose of lamotrigine than he would if he were not on valproic acid.   (See References)

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References:

1. Browne, T.R., & Holmes, G.L. (2004). Handbook of Epilepsy, 3rd Edition. Lippincott Williams & Wilkins, Philadelphia. (ISBN:0781743524) Advertising:
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pharmacology
Interactions of AEDs 01
Question ID: 122307205
Question written by J. Douglas Miles, (C) 2006-2009, all rights reserved.
Created: 12/24/2007
Modified: 12/24/2007
Estimated Permutations: 252000

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