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Basic Neuropathology 7
Infections 11
Myelin 09
Courtesy of Dr. Mark Cohen
The best diagnosis for this lesion is
Infections 04
Courtesy of Dr. Mark Cohen
The most likely etiology for these lesions in this AIDS patient
Infections 01
Courtesy of Dr. Mark Cohen Which of the following fungal organisms is most likely to result in this gross appearance
Adult Brain Tumor Pathology 01
Courtesy of Dr. Mark Cohen
A 50 year old woman presents with slowly worsening seizures over 9 months. Imaging of the head reveals a mass lesion. The lesion is surgically resected, and an H&E preparation of the tumor is shown in the image above.What kind of tumor is this
Pediatric Brain Tumor Pathology 01
A developmentally delayed 4 year-old male presents with several months of worsening seizures and headaches. A head CT reveals a large mass with areas of calcification. The mass is removed surgically. The image above shows an H&E stain of a section taken from the mass...
Neurooncology 02
A 59 year-old man presents to the emergency department with new onset of seizures. MRI is suggestive of a mass lesion. A biopsy is performed, and a photomicrograph of the tissue obtained is shown above.
Of the following, which is the most likely diagnosis
Basic Neuropathology 05
This is a photomicrograph of a brain biopsy stained with H&E. What is the abnormal finding in this slide
Basic Neuropathology 04
This is a photomicrograph of a brain biopsy stained with H&E.
What are the abnormal structures shown in this slide called
Cerebral Ischemia 01
In cases of mild hypoxic injury, which of the following cells are most likely to be damaged
Guess the disease!
GUESS WHAT I'M THINKING!
I'm thinking of a variant of multiple sclerosis (MS), in which optic neuritis and transverse myelitis occur together, or at least within weeks of each other. The transverse myelitis frequently leads to necrosis, and is thus...
CNS tumor pathology
Which of the following is most accurate regarding CNS tumor pathology
Pathology in Ischemic Stroke 03
A patient presents with an acute ischemic stroke and dies 6 months later. Of the following choices, which is most likely to be seen on pathological examination of the brain at autopsy
Pathology in Ischemic Stroke 02
A patient presents with an acute ischemic stroke and dies 1 week later. Of the following choices, which is most likely to be seen on pathological examination of the brain at autopsy
Pathology in Ischemic Stroke 01
A patient presents with an acute ischemic stroke and dies 18 hours after onset of symptoms. Of the following choices, which is most likely to be seen on pathology
User Forums and Comments
Re: Re: Re: Re: laminar necrosis
Thanks. S
Re: Re: Re: laminar necrosis
Not to my knowledge..M
Re: Re: laminar necrosis
Thanks. Is there any other process that causes selective loss of cortical layers III, V, and VI other than lack of oxygen
I'd better go to a dark room and ask the neuroradiologist what he or she means by laminar necrosis radiographically.
S
Re: laminar necrosis
Suzanne, Laminar necrosis is the selective loss of the metabolically specialized, and therefore more oxygen/blood flow dependent, neurons which occupy layers III, V, and VI.I've not heard of post-infectious cerebritis, so I can't help you with this...
laminar necrosis
Hoping gliageek can field this one, please:I'm reading about laminar necrosis in anoxia/hypoxia, which is defined as damage to cortical layers III and V, specifically extensive eosinophilic degeneration and death, with sparing of the other neocortical layers...
Re: Most Important Neuropathology Topics for Neurology Residents
Here's a bit on pseudopallisading necrosis in glioblastoma.
Online Course Content
Interactive Images
Sometimes, it is helpful to have extra information pop up when you mouse-over an image.This makes the content more interactive, and hopefully, allows the learner to try to determine for himself/herself what an image shows before revealing the answers. Some...
Pseudopalisading Necrosis (image)
Pseudopalisading Necrosis (image)
Basic Neuropathologic Reactions
Among the resources in this section are 5 lectures providing an overview of the basic cells of the nervous system, and their reactions to damage. For those who would prefer to read than listen:The typical neuron is pyramidal or triangular-shaped with a large,...
Polymyositis, immunohistochemical staining for CD68 x600 (image)
Necrotizing myopathy in a patient with rhabdomyolysis, H&E stained section x 400 (image)
Pontocerebellar necrosis, ventral surface of brain. (image)
Periventricular leukomalacia, coronal (image)
Unilateral hemorrhagic necrosis involving right cerebral hemisphere, coronal section (image)
Neuronal mineralization, thalamic neurons, H&E stain (image)
Kearns-Sayre syndrome, H&E section of substantia nigra x 200 (image)
Kearns-Sayre syndrome, high power H&E stained section of substantia nigra (image)
Medullary tegmental necrosis, transverse section of medulla (image)
Necrosis of gray and white matter, coronal section (image)
Parasitic Infections
Toxoplasma gondii is an obligate intracellular protozoan, found worldwide. It is now the most common cause of CNS mass lesions in patients with AIDS, occurring in 5-10% of AIDS patients. Toxoplasmosis may also cause eye disease (chorioretinitis) and congenital...
Fungal Infections
Aspergillus species grow on decaying vegetation and grain products, and are ubiquitous in the environment. Infection typically occurs in immunocompromised, usually neurtropenic, hosts. Aspergillus may also rarely produce brain abscesses and granulomas in individuals with a normal immune system...
Viral Infections
The most common causes of viral meningitis in the U.S. are nonpolio enteroviruses (coxsackie and echovirus), which often occur in summer and early fall. Infection is by the fecal-oral route, with primary viral replication in the GI and upper respiratory tracts...
Bacterial Infections
Meningitis means inflammation of the meninges, usually (but not necessarily) due to infection. Although inflammation may selectively involve the dura (pachymeningitis), it more commonly affects the pia and arachnoid membranes (leptomeningitis). Because the...
Tumors II: Glial and Glioneuronal Tumors
A. Neurons 1. As differentiated neurons do not normally divide, tumors derived from such cells (ganglion cell tumors) are rare, and when they occur are usually benign.2. As the external granular cell neurons of the cerebellum are actively replicating and migrating...
Vascular Disease 4: Other topics in vascular disease
Working from the outside in, intracranial hemorrhage may be epidural, subdural, subarachnoid, intraparechymal, or intraventricular in origin (though many do not remain localized to a single compartment). The term “hemorrhagic stroke” only applies to subarachnoid and intraparenchymal hemorrhages...
Vascular Disease 1: Reaction to ischemic injury
There are different types of ischemic injury. Ischemia can affect the entire brain, or just a particular vascular distribution. It can be brief, as in a TIA, or it can endure. The patterns of damage we see in gross and microscopic pathology reflect the focality and temporal course of the ischemia...
Viral Encephalitis
A. Herpes Simplex Virus Type 1 Encephalitis 1. Pathogenesis HSV-1 encephalitis is the most common cause of acute sporadic encephalitis in the U.S. It typically causes lip and mouth lesions (herpes labialis and stomatitis). Note the distinction from HSV-2,...
Hemorrhagic necrosis, cerebellar tonsils, inferior surface including medulla. (image)
Hemorrhagic infarct, posterior inferior cerebellar artery distribution, ventral surface of brain. (image)
Organizing Infarct, sagittal section of cerebellum (image)
Organizing Infarct, coronal section through thalamus with transverse section of spinal cord. (image)
Hemorrhagic necrosis, posterior cerebral artery circulations, coronal section through occipital lobes (image)
Bilateral cavitary necrosis, globus pallidus (image)
Anterior cerebral artery infarct, sagittal section through brain and brainstem. (image)
Hypotensive gray matter necrosis, transverse section of lumbar spinal cord (image)
Laminar Necrosis, coronal section at level of thalmus (image)
Ependymoma involving lateral ventricle, coronal section at the level of the basal ganglia (image)
Subependymal Giant Cell Astrocytoma, intraoperative smear preparation x 200 (image)
Thalamic Glioma, Sagittal section of autopsy brain (image)
Brainstem Glioma, transverse section (image)
Glioblastoma multiforme, microvascular proliferation, H&E stain x 400, labeled (image)
Glioblastoma multiforme involving cerebellum, H&E stain x 100, Labeled (image)
Glioblastoma multiforme, small cell variant, H&E stain x 200 with arrow (image)
Glioblastoma multiforme, pseudopallisading Necrosis, H&E stain x 200, Labeled (image)
Glioblastoma multiforme, pseudopallisading Necrosis, H&E stain x 200 (image)
Glioblastoma multiforme demonstrating pseudopalisading Necrosis H&E stain x 400 (image)
Glioblastoma multiforme, small cell variant, H&E stain x 200 (image)
Glioblastoma multiforme, microvascular proliferation, H&E stain x 400. (image)
Glioblastoma multiforme, coronal section at level of posterior thalamus (image)
Glioblastoma Multiforme involving cerebellar white matter, H&E Stain X 40 (image)
Primary Meningeal Melanoma, H&E stain x 400 (image)
Primary meningeal melanoma, H&E stained slide x 200. (image)
Atypical teratoid/rhabdoid tumor, sagittal section through cerebellum and brainstem, close-up, labeled (image)
Atypical teratoid/rhabdoid tumor, sagittal section through cerebellum and brainstem, close-up (image)
Atypical Meningioma (WHO Grade II) (image)
Herpes simplex encephalitis, ventral surface of brain. (image)
Herpes simplex encephalitis, coronal section through temporal lobe and basal ganglia. (image)
Herpes simplex encephalitis, coronal section through cingulate gyri, close-up. (image)
Cerebral toxoplasmosis, coronal section through temporal lobe, close-up (image)
Cerebral toxoplasmosis, coronal section at the level of the thalamus (image)
Phaeomycosis, low power H&E stained section. (image)
Phaeohyphomycosis, lateral surface of brain. (image)
Phaeohyphomycosis, coronal section of brain, close-up. (image)
Phaeohyphomycosis, basal lateral surface of brain. (image)
Mucormycosis, secondary to Zygomycetes infection, ventral surface of brain. (image)
Mucormycosis, secondary to Zygomycetes infection, coronal section through basal ganglia. (image)
Cerebral aspergillosis, brain biopsy, high-power H&E. (image)
Cerebral aspergillosis, brain biopsy, low power H&E. (image)
Gummatous neurosyphilis, low power H&E stained section (image)
Late-delayed radiation necrosis, low power H&E stain through cerebral cortex and white matter. (image)
Late-delayed radiation necrosis, coronal section of brain (image)
Late-delayed radiation necrosis, coronal section of brain (image)
Grinker Myelinopathy, Close Up of coronal section of brain (image)
Hypotensive brainstem necrosis, organizing phase, H&E stain (image)
Hypotensive Brainstem Necrosis (image)
Hypotensive brainstem necrosis (image)
Acute hypotensive brainstem necrosis, hypoglossal nucleus, H&E stain (image)
Diabetic thigh infarct x200 (image)
Cbllr GBM with arrow (image)
Pseudopalisading Necrosis Explained (image)
Bilateral Pallidal Necrosis Highlighted (image)
Bilateral pallidal necrosis (image)
Acute neuronal necrosis cerebellum 2 (image)
Acute neuronal necrosis - cerebellum (image)
Gallery Images
Limbic Encephalitis H&E 200x
Glioblastoma multiforme, microva
Glioblastoma multiforme involvin
Glioblastoma multiforme, small c
Glioblastoma multiforme, pseudop
Atypical teratoid/rhabdoid tumor
Cbllr GBM with arrow
Pseudopalisading Necrosis Explai
Bilateral Pallidal Necrosis High
Radiation Necrosis Coronal 2
Radiation Necrosis Coronal
Unilateral Hemorrhagic Necrosis
Organizing Brainstem Necrosis
Hypotensive brainstem necrosis
Hypotensive Brainstem Necrosis
Acute Brainstem Necrosis HE
Cerebellar Necrosis Abruption
Laminar And WM Necrosis Mitichon
Bilateral Tonsillar Necrosis
Bilateral Pallidal Necrosis
Laminar Necrosis
Acute neuronal necrosis cerebell
Acute neuronal necrosis - cerebe
Organizing cerebellar necrosis,
Hemorrhagic necrosis, posterior
Bilateral pallidal necrosis with
Laminar necrosis of cerebral rib
Laminar Necrosis, internal carot
GBM 02
GBM 01
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